1,2,3-Trichloropropane

Overview

EPA conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of 1,2,3-trichloropropane (TCP) that once finalized will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.

Background

The draft Toxicological Review of 1,2,3-Trichloropropane provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to 1,2,3-trichloropropane. 1,2,3-Trichloropropane is an important industrial chemical used as a solvent for oils and fats, waxes, and resins, and has also been used in paint thinner and varnish remover and as a degreasing agent. 1,2,3-Trichloropropane is also generated as a by-product of the production of other chlorinated compounds such as epichlorohydrin, and is used as an intermediate in the production of some pesticides and polymers, such as polysulfide rubbers.

This assessment contains the derivation of a chronic reference dose and a chronic reference concentration, as well as a cancer characterization and the derivation of an oral slope factor.

History/Chronology

Date	Description
2003	EPA began reviewing the toxicological assessment of 1,2,3-trichloropropane.
Nov 2007	EPA released an External Review Draft for public comment and review.
Jan 2008	EPA announces the external peer review panel meeting in a Jan 18, 2008 Federal Register Notice.
Sep 2009	EPA released the Final Toxicological Review (PDF) (247 pp, 1.9M) and accompanying Summary for 1,2,3-Trichloropropane to the IRIS Web site.

Status

Following the public review and comment period, the draft Toxicological Review will be reviewed by an external expert peer review meeting, to be announced in a proceeding Federal Register Notice.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2007-1083 (for the docket ID).

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• Toxicolgocial Review of 1,2,3-Trichloropropane (External Review Draft) (CAS No. 96-18-4) in Support of Summary Information on the Integrated Risk Information System (IRIS) (PDF)  (198  pp, 1.8 MB, about PDF)
• Charge for External Peer Review Panel Members (PDF)  (4  pp, 21.5 KB, about PDF)
• Consolidated Comments from the External Peer Review (Final) (PDF)  (111  pp, 502.9 KB, about PDF)

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Federal Register Notices

• FR Notice: Jan 18, 2008
• FR Notice: Nov 16, 2007