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Methyl tert-butyl ether (MTBE)

CASRN 1634-04-4 | DTXSID3020833

  • IRIS Summary (PDF) (25 pp, 170 K)

On this page:

  • Key IRIS
    Values
  • Chemical
    Documents
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (25 pp, 170 K) Last Updated:

Not assessed under the IRIS Program.


Reference Concentration for Inhalation Exposure (RfC) (PDF) (25 pp, 170 K) Last Updated: 09/01/1993

System RfC (mg/m3) Basis PoD Composite UF Confidence
Hepatic, Urinary, Ocular, Other 3 Increased absolute and relative liver and kidney weights and increased severity of spontaneous renal lesions (females), increased prostration (females), and swollen periocular tissue (males and females) NOAEL (HEC): 2.59 x 102
mg/m3
100 Medium

Cancer Assessment

Weight of Evidence for Cancer (PDF) (25 pp, 170 K)
Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (25 pp, 170 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (25 pp, 170 K)

Not assessed under the IRIS Program.

Chemical Documents

Sep 2008: Uncertainty And Variability In Physiologically-Based Pharmacokinetic (PBPK) Models: Key Issues And Case Studies (Final Report) (Report)

Oct 2000: IRIS Toxicological Review and Summary Documents for Methyl Tert-Butyl Ether (MTBE) (Report)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Methyl tert-butyl ether (MTBE)
  • eChemPortal - Methyl tert-butyl ether (MTBE)

Critical Effects

Hepatic
Hepatic

Ocular
Ocular

Urinary
Urinary

Chemical Structure

Methyl tert-butyl ether (MTBE)

Synonyms

  • Ether methyl tert-butylique [french]
  • Ether, tert-butyl methyl
  • HSDB 5847
  • Methyl 1,1-dimethylethyl ether
  • Methyl tert-butyl ether
  • Methyl tert-butyl ether (MTBE)
  • Methyl-tert-butyl ether
  • Methyl-tert-butylether
  • Metil-terc-butileter [spanish]
  • Propane, 2-methoxy-2-methyl-
  • t-Butyl methyl ether
  • tert-Butyl methyl ether
  • 1634-04-4
  • 2-Methoxy-2-methylpropane
  • 2-Methyl-2-methoxypropane
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